有哪些信誉好的足球投注网站a selection index for gene expression evolution and its application to the divergence between humans and chimpanzees基因表达的选择指数进化及其应用人类和黑猩猩之间的分歧.pdfVIP
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a selection index for gene expression evolution and its application to the divergence between humans and chimpanzees基因表达的选择指数进化及其应用人类和黑猩猩之间的分歧
A Selection Index for Gene Expression Evolution and Its
Application to the Divergence between Humans and
Chimpanzees
¤
Maria Warnefors* , Adam Eyre-Walker*
School of Life Sciences, University of Sussex, Brighton, United Kingdom
Abstract
The importance of gene regulation in animal evolution is a matter of long-standing interest, but measuring the impact of
selection on gene expression has proven a challenge. Here, we propose a selection index of gene expression as a
straightforward method for assessing the mode and strength of selection operating on gene expression levels. The index is
based on the widely used McDonald-Kreitman test and requires the estimation of four quantities: the within-species and
between-species expression variances as well as the sequence heterozygosity and divergence of neutrally evolving
sequences. We apply the method to data from human and chimpanzee lymphoblastoid cell lines and show that gene
expression is in general under strong stabilizing selection. We also demonstrate how the same framework can be used to
estimate the proportion of adaptive gene expression evolution.
Citation: Warnefors M, Eyre-Walker A (2012) A Selection Index for Gene Expression Evolution and Its Application to the Divergence between Humans and
Chimpanzees. PLoS ONE 7(4): e34935. doi:10.1371/journal.pone.0034935
Editor: Stephen R. Proulx, UC Santa Barbara, United States of America
Received November 20, 2011; Accepted March 9, 2012; Published April 18, 2012
Copyright: 2012 Warnefors, Eyre-Walker. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which
permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credi
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