a meta-analysis of array-cgh studies implicates antiviral immunity pathways in the development of hepatocellular carcinoma全息阵列研究的荟萃分析其中牵扯到的抗病毒免疫通路在肝细胞癌的发展.pdfVIP

A Meta-Analysis of Array-CGH Studies Implicates Antiviral Immunity Pathways in the Development of Hepatocellular Carcinoma 1. 2. 1 3 1 1 4 1 Xu Guo , Yanna Ba , Xi Ma , Jiaze An , Yukui Shang , Qichao Huang , Hushan Yang , Zhinan Chen *, Jinliang Xing1* 1 State Key Laboratory of Cancer Biology, Department of Cell Biology, Cell Engineering Research Center, The Fourth Military Medical University, Xi’an, People’s Republic of China, 2 Department of Clinical Immunology, Xijing Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China, 3 Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China, 4 Division of Population Science, Department of Medical Oncology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America Abstract Background: The development and progression of hepatocellular carcinoma (HCC) is significantly correlated to the accumulation of genomic alterations. Array-based comparative genomic hybridization (array CGH) has been applied to a wide range of tumors including HCCs for the genome-wide high resolution screening of DNA copy number changes. However, the relevant chromosomal variations that play a central role in the development of HCC still are not fully elucidated. Methods: In present study, in order to further characterize the copy number alterations (CNAs) important to HCC development, we conducted a meta-analysis of four published independent array-CGH datasets including total 159 samples. Results: Eighty five significant gains (f