a mathematical model for interpretable clinical decision support with applications in gynecology一种数学模型解释的在妇科临床决策支持应用程序.pdfVIP

A Mathematical Model for Interpretable Clinical Decision Support with Applications in Gynecology 1,2 1,2,3 3 3,4 5 Vanya M. C. A. Van Belle *, Ben Van Calster , Dirk Timmerman , Tom Bourne , Cecilia Bottomley , Lil Valentin6, Patrick Neven7,8, Sabine Van Huffel1,2, Johan A. K. Suykens1,2, Stephen Boyd9 1 Department of Electrical Engineering (ESAT-SCD), Katholieke Universiteit Leuven, Leuven, Belgium, 2 IBBT - Future Health Department, Katholieke Universiteit Leuven, Leuven, Belgium, 3 Department of Development and Regeneration, University Hospitals Leuven, Leuven, Belgium, 4 Department of Obstetrics and Gynaecology, Imperial College London, Hammersmith Campus, London, United Kingdom, 5 Chelsea and Westminster Hospital, London, United Kingdom, 6 Department of Obstetrics and ˚ ¨ ¨ Gynecology, Skane University Hospital Malmo, Lund University, Malmo, Sweden, 7 Multidisciplinary Breast Centre (MBC), University Hospitals Leuven, Leuven, Belgium, 8 Department of Gynaecological Oncology, University Hospitals Leuven, Leuven, Belgium, 9 Department of Electrical Engineering, Stanford University, Stanford, California, United States of America Abstract Background: Over time, methods for the development of clinical decision support (CDS) systems have evolved from interpretable and easy-to-use scoring systems to very complex and non-interpretable mathematical models. In order to accomplish effective decision support, CDS systems should provide information on how the model arrives at a certain decision. To address the issue of incompatibility between performance, interpretability and applicability of C