九味镇心颗粒及舍曲林治疗广泛性焦虑障碍临床观察.docVIP

九味镇心颗粒及舍曲林治疗广泛性焦虑障碍临床观察【摘要】目的： 比较中药九味镇心颗粒和舍曲林缓解广泛性焦虑障碍的疗效。方法：将本院就诊的广泛性焦虑障碍患者68例，随机分为2组，分别口服九味镇心颗粒与舍曲林两种药物，于治疗0周、1周、2周、4周、8周评定汉密顿焦虑量表、焦虑自评量表及副反应量表，比较评分变化、同时观察服药后血常规、肝功能和心电图的情况，8周后对两组分值进行比较。结果：实验组与对照组间疗效近似无显著性差异；实验组副作用少于对照组，尤其在胃肠道副作用方面；两组间心电图等实验室检查无明显异常。结论：两种药物均可用于临床，九味镇心颗粒副作用少于后者，具有一定的优势。 【关键词】九味镇心颗粒；舍曲林；疗效；HAMD；SAS，TESS。 【Abstract】Objective In order to compare the treatment results between nine taste heart particles and the Sertraline easing extensive panic disorder. Methods Collecting 68 patients in this hospital with extensive panic disorder, they were randomly divided into two groups, one group was given nine taste heart particles and the other was given the,SertralineThey both wrote the Hamilton anxiety scale, anxiety from rating scale and the side effects scale of change, and then compare the two groups mark.at the same time, we also compared routine blood, the liver result and electrocardiogram after eight weeks since taking medicine.Results It is no significant differences between the experimental group and control group effect,The side effects less than the control group, especially in gastrointestinal side effects aspects; such as the electrocardiogram and the others laboratory results have not significant differences between the two groups.Conclusion These two drugs can be used in clinical, nine taste heart particles has less side effects than the latter,it has certain advantages. 【Key words】 nine taste heart particles;Sertraline;effect;HAMD; SAS,TESS. 【中图分类号】R749.7+2 【文献标识码】B 【文章编号】1007-8231（2011）11-1892-02 广泛性焦虑障碍是在多种因素作用下出现的以焦虑、烦躁为主要特征的神经症，同时伴有明显的躯体症状如出汗、心悸、呼吸急促、尿频、运动不安等。我国焦虑症发病率约7‰，多在青年和中年期发病，女性多与男性。本研究将九味镇心颗粒和舍曲林两种缓解焦虑的药物做对照分析，报告如下：? 1 研究对象与方法 1.1 研究对象 将2010年3月至2011年3月就诊于我院精神科的焦虑障碍患者共68例，男性32例，女性36例，年龄18~52岁，平均年龄为（34.4±4.9）岁,病程平均为（2.3±1.5）年。所有患者根据随机的原则分别纳入实验组及对照组治疗。九味镇心颗粒治疗者为实验组，共34例，舍曲林治疗者为对照组，共34例。 1.2 研究材料 汉密顿焦虑量表（HAMD）主要包括14个项目，采用五级评分法。各级的标准为：无症状；轻；中等；重；极重。评定标准：总分：能较好的反映病情严重程度。总分超过29分，为严重焦虑；超过21分，有明显焦虑；超过14分，肯定有焦虑，超过7