multi-target drugs the trend of drug research and development多目标药物药物研究和开发的趋势.pdfVIP

Multi-Target Drugs: The Trend of Drug Research and Development Jin-Jian Lu, Wei Pan, Yuan-Jia Hu*, Yi-Tao Wang* State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China Abstract Summarizing the status of drugs in the market and examining the trend of drug research and development is important in drug discovery. In this study, we compared the drug targets and the market sales of the new molecular entities approved by the U.S. Food and Drug Administration from January 2000 to December 2009. Two networks, namely, the target–target and drug–drug networks, have been set up using the network analysis tools. The multi-target drugs have much more potential, as shown by the network visualization and the market trends. We discussed the possible reasons and proposed the rational strategies for drug research and development in the future. Citation: Lu J-J, Pan W, Hu Y-J, Wang Y-T (2012) Multi-Target Drugs: The Trend of Drug Research and Development. PLoS ONE 7(6): e40262. doi:10.1371/ journal.pone.0040262 Editor: Bharat B. Aggarwal, The University of Texas M. D. Anderson Cancer Center, United States of America Received March 26, 2012; Accepted June 4, 2012; Published June 29, 2012 Copyright: 2012 Lu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: Thanks for financial support of the University of Macau and the Macao Science and Technology Development Fund for this research, in which pharmacology part was supported by the projects UL016/09Y4/CMS/WYT01/ICMS, MYRG208(Y2-L4)-ICMS11-WYT and 077/2011/A3, while network part by MYRG065(Y1-L1)-ICMS11-