有哪些信誉好的足球投注网站identification of cd8+ t cell epitopes in the west nile virus polyprotein by reverse-immunology using netctl识别cd8 + t细胞抗原表位的西尼罗河病毒多蛋白通过使用netctl reverse-immunology.pdfVIP
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identificationofcd8tcellepitopesinthewestnileviruspolyproteinbyreverse-immunologyusingnetctl识别cd8t细胞抗原表位的西尼罗河病毒多蛋白通过使用netctlreverse-immunology
Identification of CD8+ T Cell Epitopes in the West Nile Virus Polyprotein by Reverse-Immunology Using NetCTL 1 2 2 1 1 3 Mette Voldby Larsen *, Alina Lelic , Robin Parsons , Morten Nielsen , Ilka Hoof , Kasper Lamberth , 2 3 2 1 Mark B. Loeb , Søren Buus , Jonathan Bramson , Ole Lund 1 Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, 2 Department of Pathology and Molecular Medicine, Institute for Molecular Medicine and Health, McMaster University, Hamilton, Ontario, Canada, 3 Division of Experimental Immunology, Institute of Medical Microbiology and Immunology, The Panum Institute, University of Copenhagen, Copenhagen, Denmark Abstract Background: West Nile virus (WNV) is a growing threat to public health and a greater understanding of the immune response raised against WNV is important for the development of prophylactic and therapeutic strategies. Methodology/Principal Findings: In a reverse-immunology approach, we used bioinformatics methods to predict WNV- specific CD8+ T cell epitopes and selected a set of peptides that constitutes maximum coverage of 20 fully-sequenced WNV strains. We then tested these putative epitopes for cellular reactivity in a cohort of WNV-infected patients. We identified 26 new CD8+ T cell epitopes, which we propose are restricted by 11 different HLA class I alleles. Aiming for optimal coverage of human populations, we suggest that 11 of these new WNV epitopes would be sufficient to cover from 48% to 93% of ethnic populations in various areas of the World. Conclusions/Significance: The 26 identified CD8+ T cell ep
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