有哪些信誉好的足球投注网站multiparameter phospho-flow analysis of lymphocytes in early rheumatoid arthritis implications for diagnosis and monitoring drug therapy多参数phospho-flow分析淋巴细胞在早期诊断和监测药物治疗类风湿性关节炎的影响.pdfVIP
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multiparameter phospho-flow analysis of lymphocytes in early rheumatoid arthritis implications for diagnosis and monitoring drug therapy多参数phospho-flow分析淋巴细胞在早期诊断和监测药物治疗类风湿性关节炎的影响
Multiparameter Phospho-Flow Analysis of Lymphocytes in Early Rheumatoid Arthritis: Implications for Diagnosis and Monitoring Drug Therapy 1 2 3 4 4 Carole L. Galligan , Janet C. Siebert , Katherine A. Siminovitch , Edward C. Keystone , Vivian Bykerk , 5¤ 1 Omar D. Perez , Eleanor N. Fish * 1Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada, 2 CytoAnalytics, Analytical Services, Denver, Colorado, United States of America, 3 Mount Sinai Hospital Samuel Lunenfeld and Toronto Hospital Research Institutes, Toronto, Ontario, Canada, 4 University of Toronto and Mount Sinai Hospital, Toronto, Ontario, Canada, 5 The Baxter Laboratory for Genetic Pharmacology, Stanford University School of Medicine, Stanford, California, United States of America Abstract Background: The precise mechanisms involved in the initiation and progression of rheumatoid arthritis (RA) are not known. Early stages of RA often have non-specific symptoms, delaying diagnosis and therapy. Additionally, there are currently no established means to predict clinical responsiveness to therapy. Immune cell activation is a critical component therefore we examined the cellular activation of peripheral blood mononuclear cells (PBMCs) in the early stages of RA, in order to develop a novel diagnostic modality. Methods and Findings: PBMCs were isolated from individuals diagnosed with early RA (ERA) (n = 38), longstanding RA (n = 10), osteoarthritis (OA) (n = 19) and from healthy individuals (n = 10). PBMCs were examined for activation of 15 signaling effectors, using phosphorylation status as a measure of activation in immunophenotyped cell
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