multiple chlamydiaceae species in trachoma implications for disease pathogenesis and control多个疾病发病机理在沙眼衣原体科物种的影响和控制.pdfVIP

PLoS MEDICINE Multiple Chlamydiaceae Species in Trachoma: Implications for Disease Pathogenesis and Control 1,2,3* 4 4 5 Deborah Dean , Ram P. Kandel , Him K. Adhikari , Tracey Hessel 1 Center for Immunobiology and Vaccine Development, Children’s Hospital Oakland Research Institute, Oakland, California, United States of America, 2 Department of Medicine, University of California at San Francisco, California, United States of America, 3 Joint Graduate Group in Bioengineering, University of California, Berkeley, and University of California, San Francisco, California, United States of America, 4 Department of Ophthalmology, Lumbini Rana-Ambika Eye Hospital, Bhairahawa, Nepal 5 Department of Pediatrics, University of California at San Francisco, California, United States of America Funding: This research was A B S T R A C T supported by Public Health Service Grants R01 EY/AI 012219 and R01 AI059647 from the National Background Institutes of Health (to DD) and the Rainer’s Fund (to TH). TH was a Chlamydia trachomatis is a unique obligate intracellular bacterium that remains the leading cause of Howard Hughes Medical Institute Medical Student Research Training sexually transmitted bacterial diseases and preventable blindness worldwide. Chronic ocular infections are Fellow. The funders had no role in referred to as trachoma, and predominate in developing countries. Since 2001, the World Health study design, data collection and Organization has promoted control strategies including antibiotics, improved hygiene, and environmental analysis, decisi