有哪些信誉好的足球投注网站identification and comparative analysis of the protocadherin cluster in a reptile, the green anole lizard识别和比较分析protocadherin集群的爬行动物,绿色的变色龙蜥蜴.pdfVIP
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identification and comparative analysis of the protocadherin cluster in a reptile, the green anole lizard识别和比较分析protocadherin集群的爬行动物,绿色的变色龙蜥蜴
Identification and Comparative Analysis of the Protocadherin Cluster in a Reptile, the Green Anole Lizard 1,2 1 3 3 1 Xiao-Juan Jiang , Shaobing Li , Vydianathan Ravi , Byrappa Venkatesh , Wei-Ping Yu * 1 Gene Regulation Laboratory, National Neuroscience Institute, Singapore, Singapore, 2 School of Life Sciences, Shandong University, Jinan, China, 3 Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore Abstract Background: The vertebrate protocadherins are a subfamily of cell adhesion molecules that are predominantly expressed in the nervous system and are believed to play an important role in establishing the complex neural network during animal development. Genes encoding these molecules are organized into a cluster in the genome. Comparative analysis of the protocadherin subcluster organization and gene arrangements in different vertebrates has provided interesting insights into the history of vertebrate genome evolution. Among tetrapods, protocadherin clusters have been fully characterized only in mammals. In this study, we report the identification and comparative analysis of the protocadherin cluster in a reptile, the green anole lizard (Anolis carolinensis). Methodology/Principal Findings: We show that the anole protocadherin cluster spans over a megabase and encodes a total of 71 genes. The number of genes in the anole protocadherin cluster is significantly higher than that in the coelacanth (49 genes) and mammalian (54–59 genes) clusters. The anole protocadherin genes are organized into four subclusters: the d, a, b and c. This subcluster organization is identical to that of the coelacanth protocadherin cluster, but differs from the
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