identification and characterization of peripheral t-cell lymphoma-associated serex antigens识别和描述的外周t细胞lymphoma-associated serex抗原.pdfVIP

Identification and Characterization of Peripheral T-Cell Lymphoma-Associated SEREX Antigens 1,2. 1,3 . 1 4 Christopher D. O. Cooper , Charles H. Lawrie * , Amanda P. Liggins , Graham P. Collins , 4 1 1 Christian S. R. Hatton , Karen Pulford , Alison H. Banham * 1 Nuffield Department of Clinical Laboratory Sciences, Oxford NIHR Biomedical Research Centre, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, ´ 2 Structural Genomics Consortium, University of Oxford, Oxford, United Kingdom, 3 Biodonostia Institute, San Sebastian, Spain, 4 Department of Haematology, John Radcliffe Hospital, Oxford, United Kingdom Abstract Peripheral T-cell lymphomas (PTCL) are generally less common and pursue a more aggressive clinical course than B-cell lymphomas, with the T-cell phenotype itself being a poor prognostic factor in adult non-Hodgkin lymphoma (NHL). With notable exceptions such as ALK+ anaplastic large cell lymphoma (ALCL, ALK+), the molecular abnormalities in PTCL remain poorly characterised. We had previously identified circulating antibodies to ALK in patients with ALCL, ALK+. Thus, as a strategy to identify potential antigens associated with the pathogenesis of PTCL, not otherwise specified (PTCL, NOS), we screened a testis cDNA library with sera from four PTCL, NOS patients using the SEREX (serological analysis of recombinant cDNA expression libraries) technique. We identified nine PTCL, NOS-associated antigens whose immunological reactivity was further investi