identification of 20-hydroxyecdysone late-response genes in the chitin biosynthesis pathway识别20-hydroxyecdysone反应慢几丁质生物合成途径的基因.pdfVIP
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identification of 20-hydroxyecdysone late-response genes in the chitin biosynthesis pathway识别20-hydroxyecdysone反应慢几丁质生物合成途径的基因
Identification of 20-Hydroxyecdysone Late-Response Genes in the Chitin Biosynthesis Pathway 1 1 1,2 1 1 1 1 Qiong Yao , Daowei Zhang , Bin Tang , Jie Chen , Jing Chen , Liang Lu , Wenqing Zhang * 1 State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China, 2 Hangzhou Key Laboratory of Animal Adaptation and Evolution, Hangzhou Normal University, Hangzhou, China Abstract Background: 20-hydroxyecdysone (20E) and its receptor complex ecdysone receptor (EcR) and ultraspiracle (USP) play a crucial role in controlling development, metamorphosis, reproduction and diapause. The ligand-receptor complex 20E-EcR/ USP directly activates a small set of early-response genes and a much larger set of late-response genes. However, ecdysone- responsive genes have not been previously characterized in the context of insect chitin biosynthesis. Principal Findings: Here, we show that injection-based RNA interference (RNAi) directed towards a common region of the two isoforms of SeEcR in a lepidopteron insect Spodoptera exigua was effective, with phenotypes including a high mortality prior to pupation and developmental defects. After gene specific RNAi, chitin contents in the cuticle of an abnormal larva significantly decreased. The expression levels of five genes in the chitin biosynthesis pathway, SeTre-1, SeG6PI, SeUAP, SeCHSA and SeCHSB, were significantly reduced, while there was no difference in the expression of SeTre-2 prior to 72 hr after injection of EcR dsRNA. Meanwhile, injection of 20E in vivo induced the expression of the five genes mentioned above. Moreover, the SeTre-1, SeG6PI, SeUAP and SeCHSB genes showed late responses to the hormone and the induction of SeTre- 1, Se
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