有哪些信誉好的足球投注网站host-derived smooth muscle cells accumulate in cardiac allografts role of inflammation and monocyte chemoattractant protein 1host-derived平滑肌细胞积聚在心脏移植的角色炎症和单核细胞化学引诱物蛋白1.pdfVIP
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host-derived smooth muscle cells accumulate in cardiac allografts role of inflammation and monocyte chemoattractant protein 1host-derived平滑肌细胞积聚在心脏移植的角色炎症和单核细胞化学引诱物蛋白1
Host-Derived Smooth Muscle Cells Accumulate in Cardiac Allografts: Role of Inflammation and Monocyte Chemoattractant Protein 1 1,2. 1. 2,3 2,4 5 Piotr Religa *, Monika K. Grudzinska , Krzysztof Bojakowski , Joanna Soin , Jerzy Nozynski , 5 2 5 ¨ ´ 1 Michal Zakliczynski , Zbigniew Gaciong , Marian Zembala , Cecilia Soderberg-Naucler 1 Cellular and Molecular Immunology, Karolinska Institute, Stockholm, Sweden, 2 Department of Internal Medicine and Hypertension, Warsaw University of Medicine, Warsaw, Poland, 3 Department of General, Vascular and Oncologic Surgery, Warsaw University of Medicine, Warsaw, Poland, 4 Department of General Biochemistry and Nutrition, Warsaw University of Medicine, Warsaw, Poland, 5 Silesian Center for Heart Diseases, Zabrze, Poland Abstract Transplant arteriosclerosis is characterized by inflammation and intimal thickening caused by accumulation of smooth muscle cells (SMCs) both from donor and recipient. We assessed the relationship between clinical factors and the presence of host-derived SMCs in 124 myocardial biopsies from 26 consecutive patients who received hearts from opposite-sex donors. Clinical and demographic information was obtained from the patients’ medical records. Host-derived SMCs accounted for 3.35 62.3% of cells in arterioles (range, 0.08–12.51%). As shown by linear regression analysis, an increased number of SMCs was associated with rejection grade (mean, 1.4161.03, p = 0.034) and the number of leukocytes (19.1612.7 per 20 high-power fields, p = 0.01). The accumulation o
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