有哪些信誉好的足球投注网站identification of a variable number of tandem repeats polymorphism and characterization of lef-1 response elements in the promoter of the ido1 gene数量可变的串联重复序列多态性的识别和表征lef-1响应元素ido1基因的启动子.pdfVIP
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identification of a variable number of tandem repeats polymorphism and characterization of lef-1 response elements in the promoter of the ido1 gene数量可变的串联重复序列多态性的识别和表征lef-1响应元素ido1基因的启动子
Identification of a Variable Number of Tandem Repeats Polymorphism and Characterization of LEF-1 Response Elements in the Promoter of the IDO1 Gene 1 1 1 2 2,3 Marion Soichot , Benjamin Hennart , Alaa Al Saabi , Audrey Leloire , Philippe Froguel , Claire Levy- 4 2 1 Marchal , Odile Poulain-Godefroy , Delphine Allorge * ´ ´ ´ 1 Equipe d’Accueil 4483, Faculte de Medecine de Lille, UDSL, Universite Lille-Nord de France, Lille, France, 2 CNRS 8199 - Institute of Biology, Pasteur Institute, Lille 2 ´ University, Lille, France, 3 Genomic Medicine, Imperial College London, Hammersmith Hospital, London, England, 4 Institut National de la Sante et de la Recherche ´ ˆ ´ Medicale, CIC EC 05, Hopital Robert Debre, Paris, France Abstract Background: Indoleamine 2,3-dioxygenase (IDO) catalyzes the first and rate-limiting step of the kynurenine pathway that is an important component of immunomodulatory and neuromodulatory processes. The IDO1 gene is highly inducible by IFN- c and TNF-a through interaction with cis-acting regulatory elements of the promoter region. Accordingly, functional polymorphisms in the IDO1 promoter could partly explain the interindividual variability in IDO expression that has been previously documented. Methodology/Principal Findings: A PCR-sequencing strategy, applied to DNA samples from healthy Caucasians, allowed u
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