有哪些信誉好的足球投注网站identification of a pa-binding peptide with inhibitory activity against influenza a and b virus replicationpa-binding肽的识别与抑制活动针对甲型和乙型流感病毒复制.pdfVIP
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identification of a pa-binding peptide with inhibitory activity against influenza a and b virus replicationpa-binding肽的识别与抑制活动针对甲型和乙型流感病毒复制
Identification of a PA-Binding Peptide with Inhibitory Activity against Influenza A and B Virus Replication 1. 1. 2,3 1 ¨ 1 Kerstin Wunderlich , Daniel Mayer , Charlene Ranadheera , Anne-Sophie Holler , Benjamin Manz , 1 1 4 4 2 1 Arnold Martin , Geoffrey Chase , Werner Tegge , Ronald Frank , Ulrich Kessler , Martin Schwemmle * 1 Department of Virology, University of Freiburg, Freiburg, Germany, 2 PiKe Pharma GmbH, Zurich, Switzerland, 3 Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH), Zurich, Switzerland, 4 Department of Chemical Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany Abstract There is an urgent need for new drugs against influenza type A and B viruses due to incomplete protection by vaccines and the emergence of resistance to current antivirals. The influenza virus polymerase complex, consisting of the PB1, PB2 and PA subunits, represents a promising target for the development of new drugs. We have previously demonstrated the feasibility of targeting the protein-protein interaction domain between the PB1 and PA subunits of the polymerase complex of influenza A virus using a small peptide derived from the PA-binding domain of PB1. However, this influenza A virus-derived peptide did not affect influenza B virus polymerase activity. Here we report that the PA-binding domain of the polymerase subunit PB1 of influenza A and B viruses is highly conserved and that mutual amino acid exchange shows that they cannot be functionally exchanged with each other. Ba
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