identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis共享遗传易感性位点的识别冠心病和牙周炎.pdfVIP

Identification of a Shared Genetic Susceptibility Locus for Coronary Heart Disease and Periodontitis 1 1 2 3 4 Arne S. Schaefer *, Gesa M. Richter , Birte Groessner-Schreiber , Barbara Noack , Michael Nothnagel , 5 6 7 1 Nour-Eddine El Mokhtari , Bruno G. Loos , Søren Jepsen , Stefan Schreiber 1 Institute for Clinical Molecular Biology, University Medical Center Schleswig-Holstein, Kiel, Germany, 2 Department of Operative Dentistry and Periodontology, University ¨ ¨ Medical Center Schleswig-Holstein, Kiel, Germany, 3 University Medical Center Carl Gustav Carus der Technischen Universitat Dresden, Zentrum fur Zahn-, Mund- und ¨ Kieferheilkunde, Poliklinik fur Zahnerhaltung, Dresden, Germany, 4 Institute of Medical Informatics and Statistics, University Medical Center Schleswig-Holstein, Kiel, Germany, 5 Clinic of Cardiology, University Medical Center Schleswig-Holstein, Kiel, Germany, 6 Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), VU University Amsterdam, Amsterdam, The Netherlands, 7 Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany Abstract Recent studies indicate a mutual epidemiological relationship between coronary heart disease (CHD) and periodontitis. Both diseases are associated with similar risk factors and are characterized by a chronic inflammatory process. In a candidate- gene association study, we identify an association of a genetic susceptibility