host-species transferrin receptor 1 orthologs are cellular receptors for nonpathogenic new world clade b arenaviruses宿主种类转铁蛋白受体1直接同源细胞受体不致病的新世界支系b沙粒病毒.pdfVIP

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host-species transferrin receptor 1 orthologs are cellular receptors for nonpathogenic new world clade b arenaviruses宿主种类转铁蛋白受体1直接同源细胞受体不致病的新世界支系b沙粒病毒.pdf

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host-species transferrin receptor 1 orthologs are cellular receptors for nonpathogenic new world clade b arenaviruses宿主种类转铁蛋白受体1直接同源细胞受体不致病的新世界支系b沙粒病毒

Host-Species Transferrin Receptor 1 Orthologs Are Cellular Receptors for Nonpathogenic New World Clade B Arenaviruses 1,2,3. 1. ´ ˜ 4 1 5 Jonathan Abraham , Jo Ann Kwong , Cesar G. Albarino , Jiajie G. Lu , Sheli R. Radoshitzky , Jorge 6 5 4 1 Salazar-Bravo , Michael Farzan , Christina F. Spiropoulou *, Hyeryun Choe * 1 Department of Medicine, Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, 2 Laboratory of Molecular Medicine, Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, 3 Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America, 4 Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America, 5 Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Center, Southborough, Massachusetts, United States of America, 6 Department of Biological Sciences, Texas Tech University, Lubbock, Texas, United States of America Abstract The ability of a New World (NW) clade B arenavirus to enter cells using human transferrin receptor 1 (TfR1) strictly correlates with its ability to cause hemorrhagic fever. Amapari (AMAV) and Tacaribe (TCRV), two nonpathogenic NW clade B arenaviruses that do not use human TfR1, are closely related to the NW arenaviruses that cause hemorrhagic fevers. Here we show that pseudotyped viruses bearing the surface glycoprotein (GP) of AMAV or TCRV can infect cells using the TfR1 ortholo