human fasl gene is a target of β-catenint-cell factor pathway and complex fasl haplotypes alter promoter functions人类fasl基因的目标β-catenint-cell因子通路和复杂fasl单体型改变启动子功能.pdfVIP

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human fasl gene is a target of β-catenint-cell factor pathway and complex fasl haplotypes alter promoter functions人类fasl基因的目标β-catenint-cell因子通路和复杂fasl单体型改变启动子功能.pdf

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human fasl gene is a target of β-catenint-cell factor pathway and complex fasl haplotypes alter promoter functions人类fasl基因的目标β-catenint-cell因子通路和复杂fasl单体型改变启动子功能

Human FasL Gene Is a Target of b-Catenin/T-Cell Factor Pathway and Complex FasL Haplotypes Alter Promoter Functions 1 2 1 2 3 1 Jianming Wu *, Maureen H. Richards , Jinhai Huang , Lena Al-Harthi , Xiulong Xu , Rui Lin , Fenglong 4 4 4 4 Xie , Andrew W. Gibson , Jeffrey C. Edberg , Robert P. Kimberly 1 Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, Minnesota, United States of America, 2 Department of Immunology and Microbiology, Rush Presbyterian St. Luke’s Medical Center, Chicago, Illinois, United States of America, 3 Department of General Surgery, Rush Presbyterian St. Luke’s Medical Center, Chicago, Illinois, United States of America, 4 Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America Abstract FasL expression on human immune cells and cancer cells plays important roles in immune homeostasis and in cancer development. Our previous study suggests that polymorphisms in the FasL promoter can significantly affect the gene expression in human cells. In addition to the functional FasL SNP -844C.T (rs763110), three other SNPs (SNP -756A .G or rs2021837, SNP -478A.T or r and SNP -205 C .G or r exist in the proximal FasL promoter. In the current study, we established three major FasL hyplotypes in humans. Interestingly, a transcription motif search revealed that the FasL promoter possessed two consensus T-cell factor (TCF/LEF1) binding elements (TBEs), which is either polymorphic (SNP -205C.G) or close to the functional S