有哪些信誉好的足球投注网站human intestinal dendritic cells decrease cytokine release against salmonella infection in the presence of lactobacillus paracasei upon tlr activation人类肠道树突状细胞细胞因子释放减少对沙门氏菌感染的乳酸菌paracasei tlr激活.pdfVIP
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human intestinal dendritic cells decrease cytokine release against salmonella infection in the presence of lactobacillus paracasei upon tlr activation人类肠道树突状细胞细胞因子释放减少对沙门氏菌感染的乳酸菌paracasei tlr激活
Human Intestinal Dendritic Cells Decrease Cytokine Release against Salmonella Infection in the Presence of Lactobacillus paracasei upon TLR Activation 1 ˜ 1 1 2 Miriam Bermudez-Brito , Sergio Munoz-Quezada , Carolina Gomez-Llorente , Esther Matencio , ´ 2, Fernando Romero2, Angel Gil 1* Marıa J. Bernal ´ 1 Institute of Nutrition and Food Technology Jose Mataix, Biomedical Research Centre, Department of Biochemistry and Molecular Biology II, University of Granada, Granada, Spain, 2 Hero Institute for Infant Nutrition, Hero Spain, Alcantarilla, Murcia, Spain Abstract Probiotic bacteria have been shown to modulate immune responses and could have therapeutic effects in allergic and inflammatory disorders. However, little is known about the signalling pathways that are engaged by probiotics. Dendritic cells (DCs) are antigen-presenting cells that are involved in immunity and tolerance. Monocyte-derived dendritic cells (MoDCs) and murine DCs are different from human gut DCs; therefore, in this study, we used human DCs generated from CD34+ progenitor cells (hematopoietic stem cells) harvested from umbilical cord blood; those DCs exhibited surface antigens of dendritic Langerhans cells, similar to the lamina propria DCs in the gut. We report that both a novel probiotic strain isolated from faeces of exclusively breast-fed newborn infants, Lactobacillus paracasei CNCM I-4034, and its cell-free culture supernatant (CFS) decre
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