high-resolution comparative genomic hybridization of inflammatory breast cancer and identification of candidate genes高分辨率的炎性乳腺癌的比较基因组杂交和候选基因的识别.pdfVIP
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high-resolution comparative genomic hybridization of inflammatory breast cancer and identification of candidate genes高分辨率的炎性乳腺癌的比较基因组杂交和候选基因的识别
High-Resolution Comparative Genomic Hybridization of Inflammatory Breast Cancer and Identification of Candidate Genes 1. 1. ´ ¨ 1 1 2 Ismahane Bekhouche , Pascal Finetti , Jose Adelaıde , Anthony Ferrari , Carole Tarpin , Emmanuelle Charafe-Jauffret1,3,4, Colette Charpin3,5, Gilles Houvenaeghel6, Jocelyne Jacquemier 1,4, Ghislain Bidaut7, Daniel Birnbaum1, Patrice Viens2,3, Max Chaffanet 1, Franc¸ois Bertucci1,2,3* 1 Marseille Cancer Research Center (CRCM), UMR891 Inserm, Institut Paoli-Calmettes (IPC), Department of Molecular Oncology, Marseille, France, 2 Department of Medical ´ ´ ´ Oncology, Institut Paoli-Calmettes (IPC), Marseille, France, 3 Universite de la Mediterranee, Marseille, France, 4 Department of BioPathology, Institut Paoli-Calmettes (IPC), ˆ Marseille, France, 5 Department of Pathology, Hopital Nord, Marseille, France, 6 Department of Surgery, Institut Paoli-Calmettes (IPC), Marseille, France, 7 Bioinformatics, Marseille Cancer Research Center (CRCM), Marseille, France Abstract Background: Inflammatory breast cancer (IBC) is an aggressive form of BC poorly defined at the molecular level. We compared the molecular portraits of 63 IBC and 134 non-IBC (nIBC) clinical samples. Methodology/Findings: Genomic imbalances of 49 IBCs and 124 nIBCs were determined using high-resolution array- comparative genomic hybridization, and mRNA expression profiles of 197 samples using whole-genome microarrays. G
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