有哪些信誉好的足球投注网站human endogenous retrovirus expression is inversely associated with chronic immune activation in hiv-1 infection人类内源性逆转录病毒表达与慢性免疫激活在hiv - 1感染呈负相关.pdfVIP
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human endogenous retrovirus expression is inversely associated with chronic immune activation in hiv-1 infection人类内源性逆转录病毒表达与慢性免疫激活在hiv - 1感染呈负相关
Human Endogenous Retrovirus Expression Is Inversely Associated with Chronic Immune Activation in HIV-1 Infection 1 2. 2. 3 4 Christopher E. Ormsby *, Devi SenGupta , Ravi Tandon , Steven G. Deeks , Jeffrey N. Martin , R. 5 5 2 ´ ´ 1 ´ 1 Brad Jones , Mario A. Ostrowski , Keith E. Garrison , Joel A. Vazquez-Perez , Gustavo Reyes-Teran , Douglas F. Nixon2 1 Center for Research in Infectious Diseases, National Institute of Respiratory Diseases, Mexico City, Federal District, Mexico, 2 Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America, 3 Positive Health Program, San Francisco General Hospital, San Francisco, California, United States of America, 4 Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America, 5 Department of Immunology, University of Toronto, Toronto, Ontario, Canada Abstract Human endogenous retroviruses (HERV) are remnants of ancestral retroviral infections integrated into the germ line, and constitute approximately 8% of the genome. Several autoimmune disorders, malignancies, and infectious diseases such as HIV-1 are associated with higher HERV expression. The degree to which HERV expression in vivo results in persistent inflammation is not known. We studied the association of immune activation and HERV-K expression in 20 subjects with chronic, untreated progressive HIV-1 infection and 10 HIV-1
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