human herpesvirus-8 infection leads to expansion of the preimmunenatural effector b cell compartment人类疱疹病毒8型感染导致的扩张preimmunenatural效应b细胞室.pdfVIP

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human herpesvirus-8 infection leads to expansion of the preimmunenatural effector b cell compartment人类疱疹病毒8型感染导致的扩张preimmunenatural效应b细胞室.pdf

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human herpesvirus-8 infection leads to expansion of the preimmunenatural effector b cell compartment人类疱疹病毒8型感染导致的扩张preimmunenatural效应b细胞室

Human Herpesvirus-8 Infection Leads to Expansion of the Preimmune/Natural Effector B Cell Compartment 1 1 1 2 2 Silvia Della Bella *, Adriano Taddeo , Elena Colombo , Lucia Brambilla , Monica Bellinvia , Fabrizio 3 1 ` 4 1 Pregliasco , Monica Cappelletti , Maria Luisa Calabro , Maria Luisa Villa 1 Department of Biomedical Sciences and Technologies, University of Milan, Milan, Italy, 2 Institute of Dermatological Sciences, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy, 3 Department of Public Health, Microbiology and Virology, University of Milan, Milan, Italy, 4 Immunology and Diagnostic Molecular Oncology, Istituto Oncologico Veneto, IOV-IRCCS, Padova, Italy Abstract Background: Human herpesvirus-8 (HHV-8) is the etiological agent of Kaposi’s sarcoma (KS) and of some lymphoproliferative disorders of B cells. Most malignancies develop after long-lasting viral dormancy, and a preventing role for both humoral and cellular immune control is suggested by the high frequency of these pathologies in immunosuppressed patients. B cells, macrophages and dendritic cells of peripheral lymphoid organs and blood represent the major reservoir of HHV-8. Due to the dual role of B cells in HHV-8 infection, both as virus reservoir and as agents of humoral immune control, we analyzed the subset distribution and the functional state of peripheral blood B cells in HHV-8- infected individuals with and without cKS. Methodology/Principal