脑梗死患者高敏C反应蛋白水平变化的临床意义.pdfVIP

志2008年O3月 2 鲞 Q 剔 堕￡』丛 鱼 2 2 S=Q ：Q · 279· 临床研究 脑梗死患者 · 论 著· 高敏C反应蛋白水平变化的临床意义 贺志遥 (怀化市第五人民医院检验科，湖南怀化 418000) ● 【摘 要】 目的 探讨脑梗死(c1)患者血清高敏c反应蛋白(hs—CRP)水平与病情严重程度及预后的关 系。方法 采用胶乳增强免疫比浊法分别测定80例CI患者人院24h内(急性期组)和治疗2周后(恢复期 组)的血清hs-CRP水平，选择年龄、性别相匹配的 期健康体检者80例作刘‘照。观察不 大小梗死灶和 不同神经功能缺损程度的cl患者血清hs—CRP水平变化。结果 急性期组和恢复期组的血清hs—CRP水 平明显高于对照组 均0．00I)，J=L急性期组血清hs—CRP水平明 高于恢复期组(P0．0I)；大面积梗死cl 患者hs-CRP水平明显高于小面积c』患者(均P0．01)；神经功能缺损程度越严重，hs—CRP水平越高(J【) 均0．01)。结论 血清hs—CRP水平反映了Cl患者的梗死面积和神经功能缺损程度，可用于Cl患者病情 的判断和预后的评估。 【关键词】脑梗死 高敏C反应蛋白 炎症 【中图分类号I R743．22 I文献标识码】A Clinical signficance of high-sensitivity C-reactive protein measurement in cerebral infarction HE ZHi—yao．Dept．of Clinical Laboratories，Huaihua City Fifth People S Hospital，Huaihua 418000，China 【Abstract】 Objective To investigate the correlation of serunl high-sensitivity e—reactive protein(hs— CRP)and disease severity and prignosis in cerebral infarction(C1)．Methods The particle—enhanced immunoturbidimetric assay was used to measure the serum hs—CRP levels both in 80 CI cases within 24h at admission (acute stage group)and 2wk after treatment(recovery stage group)，as compared with those in 80 age-and gentler—matched healthy controls．|rhe hs—ClIP level alterations were observed in varying infarction sizes anti neurological deficits ill CI patients．Results The hs—CRP levels Were considerably higher in both the acute and recovery stage group than in the controlled group(P0．0 1)，and the hs-CRP level was substantially higher in the acute stage group than in the recovery group )0．O 1)． The hs—CRP levels in CI patients with large infarction size were markedly higher as compared to nlinor infarction size，all