加味桃核承气汤对STZ糖尿病大鼠肝、肾和心组织的抗氧化保护作用.pdfVIP

ofAnhui 安徽农业科学，Journal A酣．Sci．2013，41(30)：12052—12054，12058 责任编辑陈玉敏责任校对李岩 加昧桃核承气汤对STZ糖尿病大鼠肝、肾和心组织的抗氧化保护作用 李静，葛超，韩莲莲，刘德义，陈会良 (安徽科技学院动物科学学院’安徽凤阳233100) 摘要[目的]研究加味桃核承气汤对糖尿病大鼠的肝、肾和心脏组织抗氧化保护作用。[方法]尾静脉小剂量(45 mg／kg)注射链脲佐 茵素(STZ)复制糖尿病模型，设立对照组、糖尿病组和给药组(加味桃核承气汤10ml／mg·d)，测定第56天各组的左肾指数、右肾指数 (MDA)含量。[结果]给药组大鼠的体重较糖尿病组极显著升高(P0．01)，左肾指数和右肾指数较糖尿病组无显著变化，肝指数较糖 过氧化作用，提高糖尿病大鼠的肝、肾和心组织的抗氧化能力，缓解氧化损伤。 关键词糖尿病；桃核承气汤；链脲佐菌素；抗氧化 中图分类号$865．1+2文献标识码A 文章编号0517—6611(2013)30—12052—03 ofTaob On andHeartof DiabeticRats Decoction STZ-induced Chengqi Liver，Kidney Anti·oxidative雌cts LI etal j Scienceand of声^iIrScience，Anhui 233100) Jing (College TechnologyUniversity，Fengyang，Anhui Abstract theanti—oxidativeofTaohe Decoctionon andheartofdiabetic [Objective]Tostt．,Jy activity Chengqi liver，kidney rats．[Method] Diabeticmodelswereestablishedtailvein ofsmalldose t}lree divided：control by injection streptozotocin(45mg／kg)，thegroups group，diabetes the th andliver werede— decoction10 56 index index group，treatmentgroup(Taohe day，leftkidneyindex，rishtkidney Chengqi ml／mg·d)．At of andheart were oftreatment levels andSODin teeted，the CAT，MDA，GSH—Px liver，kidney homogenatedetected．[Result]Thebodyweight were withdiabetes indexand indexofdiabeteswereno group significantlyhigher group(P0．01)，leftkidney rightkidney group significant index reduced withdiabetes and