S100家族新成员S100P与肿瘤关系的研究进展.pdfVIP

中国医药导报 2015年4月第 12卷第 12期 窑综 述 窑 S100家族新成员S100P与肿瘤关系的研究进展 李胜水1 许 华1 韩晓春2 1.河北省沧州中西医结合医院病理科袁河北沧州 061001曰 2.河北省沧州中西医结合医院肿瘤外科袁河北沧州 061001 [摘要] 近年来S100家族成员之一S100P在人类多种恶性肿瘤中的异常表达受到日益关注袁其可能参与肿瘤细 胞异常增殖尧癌变尧促进肿瘤浸润转移袁与肿瘤分期及预后袁乃至化疗药物耐药有关遥本文就近几年关于S100P与 恶性肿瘤关系的研究进展做一综述遥 [关键词] 肿瘤曰S100P曰研究 [中图分类号] R73 [文献标识码]A [文章编号] 1673-7210渊2015冤04渊c冤-0045-05 Research progress of S100P要要要a new member of the S100 family and its relationshipwithtumor 1 1 2 LI Shengshui XU Hua HANXiaochun 1.Department of Pathology, Cangzhou Hospital of Integrated Traditional and Western Medicine, Hebei Province, Cangzhou 061001, China;2.Department of Surgical Oncology, Cangzhou Hospital of Integrated Traditional and West鄄 ern Medicine,HebeiProvince, Cangzhou 061001, China [Abstract]In recent years, the abnormal expression of S100P要要要a member of the S100 family in many human malig鄄 nant tumors received increasing attention. It may be involved in the abnormal proliferation of tumor cells, canceration, promoting tumor invasion and metastasis. It is associatedwith tumor staging and prognosis, aswell as chemotherapy re鄄 sistance. In this paper, the research progress on relationship between S100P and malignant tumors are reviewed in the nearestfew years. [Keywords]Tumor; S100P;Research S100P是S100蛋白家族的成员之一袁近些年来 近些年来研究发现该家族某些成员与一些恶性 国内外关于S100P与肿瘤关系的研究陆续开展并日 肿瘤有关遥 其中关于S100A2的表达与肿瘤关系的研 益受到关注遥笔者现综合国内外文献就S100P的生物 究仍存有争议袁有报道其在食管鳞癌尧结直肠癌等恶 [2] 学特性尧其与肿瘤关系的研究进展尧作用机制做一 性肿瘤中表达水平降低 袁而另有研究表明胰腺癌尧非 综述遥