医学交流课件：替格瑞洛研究概览-二期临床研究.ppt

DISPERSE2 结论 替格瑞洛 与氯比格雷有相似的安全性和耐受性 替格瑞洛, 第一个快速起效，可逆结合的P2Y12受体拮抗剂，为外科手术的灵活选择提供了可能。 Cannon CP, et al. J Am Coll Cardiol 2007;50:1844-51. Thank you * Patients who were clopidogrel responders were randomised to receive either clopidogrel or ticagrelor treatment[Gurbel:G] These patients were further randomised at the midpoint of the study to either continue on their treatment regimen or crossover to the alternative treatment regimen[Gurbel 2010:G] Gurbel PA, et al. Circulation 2010;121:1188–1199. * Ticagrelor significantly reduced high platelet reactivity in a greater proportion of patients than clopidogrel[Gurbel 2010:Q] The McNemar non-parametric test was used to compare proportional data from matched pairs This is suitable for this population because both ticagrelor and clopidogrel data are available from the same patient Gurbel PA, et al. Circulation 2010;121:1188–1199. * Ticagrelor significantly reduced high platelet reactivity in a greater proportion of patients than clopidogrel[Gurbel 2010:Q] The McNemar non-parametric test was used to compare proportional data from matched pairs This is suitable for this population because both ticagrelor and clopidogrel data are available from the same patient Gurbel PA, et al. Circulation 2010;121:1188–1199. * Patients who were clopidogrel responders were randomised to receive either clopidogrel or ticagrelor treatment[Gurbel:G] These patients were further randomised at the midpoint of the study to either continue on their treatment regimen or crossover to the alternative treatment regimen[Gurbel 2010:G] Gurbel PA, et al. Circulation 2010;121:1188–1199. * Ticagrelor significantly reduced high platelet reactivity in a greater proportion of patients than clopidogrel[Gurbel 2010:Q] The McNemar non-parametric test was used to compare proportional data from matched pairs This is suitable for this population because both ticagrelor and clopidogrel data are available from the same patient Gurbel PA, et al. Circulation 2010