血氧水平依赖磁共振成像评价慢性肾脏疾病的初步分析-preliminary analysis of blood oxygen level dependent magnetic resonance imaging in evaluating chronic renal diseases.docxVIP

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血氧水平依赖磁共振成像评价慢性肾脏疾病的初步分析-preliminary analysis of blood oxygen level dependent magnetic resonance imaging in evaluating chronic renal diseases.docx

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血氧水平依赖磁共振成像评价慢性肾脏疾病的初步分析-preliminary analysis of blood oxygen level dependent magnetic resonance imaging in evaluating chronic renal diseases

血氧水平依赖磁共振成像评价慢性肾脏疾病的初步研究英文摘要A preliminary study of blood-oxygen-level-dependent MRI for the assessment of chronic kidney diseaseAbstractObjective:To explore the clinical application of blood-oxygen-level-dependent MRI for the assessment of chronic kidney disease.Methods:Twelve healthy volunteers were recruited as the control group in this study. Thirty-one patients with chronic kidney disease, who were enrolled from February 2013 to September 2013, were separated into three group (stage 1-2 CKD as mild group, stage 3-4 CKD as moderate group, stage 5 CKD as severe group). Regular T1WI and T2WI sequence and mGRE BOLD sequence were performed in Siemens Verio 3.0T MR. R2* values of bilateral cortex and medulla were measured and calculated by two radiologists using Siemens Syngo software. The differences of cortical and medullary R2* between control group and CKD group were compared with independent-samples t test, while the differences between cortical and medullary R2* in each group were analyzed with paired t test. One-way ANOVA was adopted to compare the cortical and medullary R2* among the control group and three CKD groups. To explore further differences, LSD was performed to compare four groups one another. ROC curve was used to analyze the diagnostic performance of differences between groups identified by medulla R2*, and the optimum threshold was determined. P0.05 was considered to indicate a significant difference in all tests.Results:On the R2* images, renal cortex could be clearly differentiated from medulla with the color change form blue to green, yellow till red.The medullary R2* was higher than that of renal cortex in both control group and英文摘要血氧水平依赖磁共振成像评价慢性肾脏疾病的初步研究CKD group. There was a significant difference between the cortical and medullary R2* in each group (control group: t=-20.654, P0.05; CKD group: t=-38.231, P0.05). Besides, remarkable differences of cortical and medullary R2* were observed between two groups (cortical R2*: t=-6.649, P0