高频振荡通气干预新生儿持续肺动脉高压效果评价.docVIP

高频振荡通气干预新生儿持续肺动脉高压效果评价 彭好 李琴 王春艳 遂宁市中心医院儿科 X 关注成功！ 加关注后您将方便地在 我的关注中得到本文献的被引频次变化的通知！ 新浪微博 腾讯微博 人人网 开心网 豆瓣网 网易微博 摘????要： 目的 比较高频振荡通气 (HFOV) 与常频机械通气 (CMV) 治疗新生儿持续肺动脉高压 (PPHN) 的疗效。方法 选取2013年1月至2017年6月该院新生儿重症监护病房收治的PPHN且需机械通气患儿46例作为研究对象, 采用随机数字表法分为HFOV组 (22例) 和CMV组 (24例) , 机械通气6 h后氧合指数大于25时给予口服西地那非。观察两组患儿血气分析、肺动脉压 (PAP) 改善情况及疗效等。结果 HFOV组患儿机械通气后有效率明显高于CMV组, 二氧化碳分压、氧分压、血氧饱和度、PAP改善情况均明显优于CMV组, 患儿中应用西地那非比例明显低于CMV组, 合并气胸患儿行胸腔闭式引流比例明显低于CMV组, 差异均有统计学意义 (P0.05) 。两组患儿颅内出血发生率比较, 差异无统计学意义 (P0.05) 。结论 HFOV治疗新生儿PPHN安全、有效, 值得临床推广应用。 关键词： 高频通气; 通气机, 机械; 持续性胎儿循环综合征/治疗; 治疗结果; 作者简介：彭好 (1970—) , 硕士研究生, 主任医师, 主要从事新生儿脑损伤研究工作。 收稿日期：2017-07-12 基金：四川省科技厅应用基础计划项目 (2015JY0136) Effectiveness evaluation of high frequency oscillatory ventilation in the treatment of newborns with persistent pulmonary hypertension Peng Hao Li Qin Wang Chunyan Department of Pediatrics, Suining Central Hospital; Abstract： Objective To compare the efficacy of high frequency oscillation ventilation (HFOV) and conventional mechanical ventilation (CMV) in treating newborns with persistent pulmonary hypertension (PPHN) . Methods From January 2013 to June 2017, 46 children with PPHN, who were received in neonatal ICU in the hospital and required mechanical ventilation, were selected as the research objects and divided into HFOV group (n=22) and CMV group (n=24) by random number table. The patients, the oxygenation index of whom was more than 25 after 6 h mechanical ventilation, were administrated with Sildenafil orally. The arterial blood gas analysis, pulmonary artery pressure (PAP) and efficacy in the two groups were observed. Results The effective rate in HFOV group was obviously better than that in CMV group partial. Pressure of carbon dioxide, oxygen partial pressure, oxyhemoglobin saturation and PAP in the HFOV group were remarkably superior to those in the CMV group, the proportions of the children administrated with Sildenafil and the children with thoracic closed drainage in the HFOV group were promi