儿童过敏性紫癜性肾炎相关危险因素分析.pdfVIP

蚌埠医学院学报 2013年 10月第38卷第 10期 1301 [文章编号]1000-2200(2013)10—1301-03 · 临床 医学 · 儿童过敏性紫癜性肾炎相关危险因素分析 储昭乐 [摘要]目的：探讨儿童过敏性紫癜性肾炎(HSPN)的相关危险因素。方法：回顾性分析 186例过敏性紫癜 (HSP)患儿的临床 资料，根据尿常规检查结果分为HSPN组56例和非 HSPN组 130例，采用单因素分析和多因素非条件 logistic回归分析 HSPN 的相关危险因素。结果：单因素分析提示反复皮疹、并发关节症状、消化道出血和腹痛共4个变量 因素影响 HSPN的发生 (P0．05～P0．O1)；多因素非条件 logistic回归分析表明反复皮疹、并发关节症状和腹痛是HSPN的危险因素(P0．01)。 结论：反复皮疹 、关节症状和腹痛是肾损害不可忽视的危险因素，对出现上述因素的HSP患儿应严密观察随访 ，并采取积极有 效的措施防止肾损害的发生和发展。 [关键词】紫癜；紫癜性。肾炎；儿童 ；危险因素 [中国图书资料分类法分类号]R554．6 [文献标志码]A AnalysisofcorrelatedriskfactorsofnephritisinchildrenHenoch-Schonleinpurpura CHU Zhao．1e (DepartmentofPediatrics，TongchengPeopleSHospital，TongchengAnhui231400，China) [Abstract]Objective：TostudythecorrelatedriskfactorsofchildrenHenoch—Schonleinpurpuranephritis(HSPN)．Methods：One hundredandeighty-sixHenoch—Schonleinpurpura(HSP)childrenwerereviewedandanalyzed．Accordingtotheroutineurinary examination，childrenweredividedintoHSPNgroup(n=56)andnon—HSPNgroup(n=130)，andthenmonofactorialanalysisandnon— conditionallogisticanalysiswereperformedtoevaluatetheriskfactorsinchildrenwithHSPN．Results：Inunivariateanalysis，frequent occurrenceofpurprua，arthrosissymptom ，hemorrhageofdigestivetractandabdominalpainwereidentifiedasfactorsassociatedwith nephritis(P0．05toP0．叭)．Logisticrergessionanalysisshowedthatnephritiswassignificantlyassociatedwithfrequentoccurrence ofpu~ma，arthrosissymptom andabdominalpain(P0．01)．Conclusions：Frequentoccurrenceofpu~ma，arthrosissymptom and abdominalpainarehighfactorstowardsrenal damagethatcannotbeneglected．Patientswiththeseriskfactorsshouldberigorously monitoredandneedtotakepositivemeasurestopreventthedevelopmentandprogressionofrenaldamage． [Keywords]purpura；Henoch—Schonleinpurpuranephritis；child；riskfactors 过敏性紫癜又称 亨 一舒综合征