低温高压差提取六味祛痘方在面膜液中的应用.pdfVIP

主国羞查堕堂 至 篁 鲞箜 !塑 ! alofAestheticMedicine．Oct．2013．Vo1．22N．o．19 197 · 中医药美容 · ·论著 · 低温高压差提取六味祛痘方在面膜液中的应用 吴园园 ，王颖 ，欧春凤 。，梁高卫3吴培诚 (1．赛保尔生物药业有限公司 广东 深圳 518129；2．广 I军区总医院皮肤科；3．索芙特皮肤工程与化妆品研 发中心 ；4．广东药学院基础学院) [摘要]目的：探究采用低温高压差提取六味祛痘方的体外抑菌效果。评价其对治疗痤疮的人体安全性及有效 性。方法：采用连续低温高压差提取六味中草药活性成分组成六味祛痘方，测定该复方对三种模式菌株的抑 菌圈和最低抑菌浓度 (MIC值)，并通过人体皮肤斑贴试验以及临床疗效确定其安全性及有效性。结果：该六 味祛痘方具有明显体外抑菌效果，斑贴试验阴性率 92．5％，临床疗效治疗组有效率为87．5％。结论：连续低温 高压差提取中药活性成分药效高，适合用于祛痘面膜液治疗痤疮，对人体无刺激，无不良反应，疗效显著。 [关键词]六味祛痘方；低温高压差；体外抑菌；斑贴试验；临床疗效 [中图分类号]R285．5 [文献标识码]A [文章编号]1008—6455(2013)19—1973—05 Theapplicationinmaskofthesixkindsofacneextractingbycryogenichigh pressuredifference w uYuan-yuan~,WANG Ying2,OU Chun—Feng3,LIANG Gao—weP,W U Pei—cheng (1．SCIPROGENBio—pharmaceuticalCo．，Ltd，Shenzhen518129，China；2．GeneraIHospitaIof GuangzhouMilitaryCommandofPLA，Guangzhou520000，China；3．SofttoDermatologic Engineering andCosmeticResearchCenter，Conghua510990，China；4．SchoolofBasicCoursesofGuangdong PhamarmaceuticalUniversity，Guangzhou510006。China) Abstract：Objective To explore theantibacterialeffectinvitro ofthe sixkindsofacne．which extracting by cryogenic high pressure difference．Evaluate the human efficacy and safety about treating acne．Methods Extractthe six kinds of acne by continuous cryogenic high pressure difference．Detectbacteriostatic ring ofthe compound againstthree models strains and minimum bacteriostaticconcentration (MlCvalues)．Determineitssafetyandefficacythroughthehumanbody skinpatchtestandclinicalcurative．ResultsThe compound hasobviousantibacterialeffectinvitro． Patchtestnegativerateis92．5％．Theefficiencyofclinicalefficacyofthetreatmentgroup is87．5％ ． Conclusion By continuous cryogenic high pressure difference method to extractthe effective ingredientsofChinese medicin