介入联合体部伽玛刀治疗原发性肝癌疗效分析.pdfVIP

2013年 10月 第21卷第 10期 MODERN0NC0L0GY，Oct．2013，VOL．21．NO．10 ·2281· 介入联合体部伽玛刀治疗原发性肝癌疗效分析 沙晓锋，张 娇，韦淑贞，杨青梅，张 闯，山顺林 Thetherapeuticeffectofprimaryhepaticcarcinomapatientstreatedwithtranscatheterhe- paticarterialchemoemb0Iizafion(TACE)combinedwithgammaknife(Y—knife) ShaXiaofeng，ZhangJiao，weiShuzhen，YangQingmei，ZhangChuang，ShanShunlin The82ndHospitalPLA，JiangsuHuai~n223001，China． 【Abstract】 Objective：Toexploretheclinicaleffectandtoxicityoftranscatheterhepaticarterialchemoembolization (TACE)combinedwithgammaknifetreatmentonpatientsofprimaryhepaticcarcinoma．Methods：All105patients withhepatocellularcarcinomaweredividedintotwogroupsrandomly：GroupA —TACE combinedwithgammaknife (combinedtherapyrgoup)52cases；GroupB—TACEonly(controlrgoup)53cases．Results：Theeffectiverateof rgoupA andgroupBwere92．3％ and67．9％ ．CBRingroupA wasmuchhigherthangroupB．Oneyearsurvivalrate ofthetwogroupswere88．5％(46)nad71．7％(38)．Threeyearsurvivalratesofthetwogroupswere40．4％(46) nad28．3％(34)．Thedecreaseofhemoglobinandplateletofthetworgoupswerebasicallythesame．Theoccurrence andplateletprobabilityofleukocytedecrease，liverfunctiondamage，nausea，vomitinginrgoupA weremuchhigher thanthatinrgoupB，butthesesymptomswouldbecuredaftertreatment．Conclusion：TACE combinedwith gamma knifecandramaticallyincreasetheshortterm effect．1ivingqualityna dsurvivaltimeofthepatientsofprimaryhepatic cracinoma．Andthesideeffectssuchasleukocytedecrease，liverfunctiondamage，nausea，vomitingincreased，butthey dontinfluencethetreatmentaftertreatment． 【Keywordslprimaryhepaticcracinoma；gammaknit(一knif_e)；interventionalangiorgaphictherapy Modem Oncology2013，21(1O)：2281—2283 【摘要】 目的：评价肝动脉化疗栓塞(TACE)联合体部伽玛刀治疗原发性肝癌的临床疗效及毒副反应。方 法：105例肝癌患者随机分为 2组：介入 +伽玛刀组(综合组)52例 ，介入治疗组(对照组)53例。比较两组治 疗后的近期疗效、临床受益疗效、生存期及毒副反应。结果：综合组、对照组有效率分别为 92．3％和67