α－干扰素及更昔洛韦治疗传染性单核细胞增多症疗效比较.docVIP

α－干扰素及更昔洛韦治疗传染性单核细胞增多症疗效比较 　 作者：岑丹阳　朱军　薛红漫　谢荣初 【摘要】 目的 比较α-干扰素（α-INF）和更昔洛韦（GCV）治疗儿童传染性单核细胞增多症（IM）的疗效。方法 222例儿童IM分为GCV治疗组(59例)、α-INF治疗组(74例)和其他药物（利巴韦林等）治疗组(89例)，3组患儿年龄、性别、病程、病情等无明显差异。GCV治疗组给以GCV 10 mg/（kg#8226;d），1次/12 h，静脉滴注，7 d后改为5 mg/（kg#8226;d），1次/d，静脉滴注，总疗程10~14 d。α-INF治疗组给以α-INF 5万U/（kg#8226;d），肌内注射，总疗程10~14 d。结果 GCV治疗组和α-INF治疗组在热程、咽峡炎改善、淋巴结、肝脾开始缩小、异型淋巴细胞恢复至lt;10%的时间等方面均优于其他药物治疗组，差异有显著性；而该两组之间上述各项指标改善的比较无统计学差异;②GCV治疗组4例出现粒细胞降低，α-INF治疗组11例出现发热，均在停药后3~7 d恢复正常。结论 应用GCV及α-INF治疗IM均可取得明显疗效，GCV与α-INF之间的疗效比较并无明显差别，两种药物均无严重不良反应。 　　【关键词】 儿童；传染性单核细胞增多症；α-干扰素；更昔洛韦 　　 　　【Abstract】 Objective To compare the therapeutic effect of GCV and α-interferon to infectious mononucleosis (IM) in children.Methods 222 patients were divided into the ganciclovir(GCV) treatment group (n=59),the α-interferon treatment group (n=74) and the control group (n=89).Among these three groups there were no differences in age,sex and patients,condition.Children in the GCVgroup were given GCV 10 mg/（kg#8226;d），q12 h，iv drip for 7 days，then 5 mg/（kg#8226;d），qd，iv drip，the whole treatment course were 10-14 days.Patients in the α-interferon group were given α-interferon 5×104U/（kg#8226;d），im，for 10-14 days.The control group were given other drugs（ribavirin，etc）.Results ①Between the GCV group and the control group,significant difference were found in the shorten of fever duration,the improvement of the angina,the diminution of the lymph node、liver and spleen and the time atypical lymphocyte decreasedlt;10%.And the same results were also found in the comparation between the α-interferon group and the control group.But there was no statistical difference between the GCV group and the α-interferon group.②In the GCVgroup granulocyte were found in 4pts，11 pts had fever in the α-interferon group，the side effects were recovered within3-7 days after drug withdrawal.Conclusion Both GCV and α-interferon are effective in the treatment of IM; And they both had no serious side effect in IM treament. 　　【Key words】 Ch