antiviral activities and putative identification of compounds in microbial extracts from the hawaiian coastal waters抗病毒活动和假定的鉴定化合物微生物提取物夏威夷沿海水域.pdfVIP

Mar. Drugs 2012, 10, 521-538; doi:10.3390/m OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article Antiviral Activities and Putative Identification of Compounds in Microbial Extracts from the Hawaiian Coastal Waters Jing Tong 1,2, Hank Trapido-Rosenthal 3, Jun Wang 4, Youwei Wang 2, Qing X. Li 4,* and Yuanan Lu 1,* 1 Department of Public Health Sciences, University of Hawaii at Manoa, East-West Road, Honolulu, HI 96822, USA; E-Mail: tongjing1975@ 2 Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, and Institute of Traditional Chinese Medicine Natural Products, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China; E-Mail: wyw@ 3 Center for Marine Microbial Ecology and Diversity, University of Hawaii at Manoa, Honolulu, HI 96822, USA; E-Mail: rosenthl@ 4 Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, East-West Road, Honolulu, HI 96822, USA; E-Mail: wangjun2@ * Authors to whom correspondence should be addressed; E-Mails: yuanan@ (Y.L.); qingl@ (Q.X.L.); Tel.: +1-808-956-2702 (Y.L.); +1-808-956-2011 (Q.X.L.); Fax: +1-808-956-5818(Y.L.); +1-808-956-3542 (Q.X.L.). Received: 25 December 2011; in revised form: 3 February 2012 / Accepted: 6 February 2012 / Published: 24 February 2012 Abstract: Marine environments are a rich source of significant bioactive compounds. The Hawaiian archipelago, located in the middle of the Pacific Ocean, hosts diverse microorganisms, including