有哪些信誉好的足球投注网站angiotensin-converting enzyme (ace) gene insertiondeletion polymorphism and ace inhibitor-related cough a meta-analysisinsertiondeletion血管紧张素转换酶(ace)基因多态性和ace inhibitor-related咳嗽一个荟萃分析.pdfVIP
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angiotensin-converting enzyme (ace) gene insertiondeletion polymorphism and ace inhibitor-related cough a meta-analysisinsertiondeletion血管紧张素转换酶(ace)基因多态性和ace inhibitor-related咳嗽一个荟萃分析
Angiotensin-Converting Enzyme (ACE) Gene Insertion/
Deletion Polymorphism and ACE Inhibitor-Related
Cough: A Meta-Analysis
1,3. 2. 4 3 3 3 2
Ya-Feng Li , Xiao-Ming Zhu , Fan Liu , Chuan-Shi Xiao , Yun-Fei Bian , Hong Li , Jun Cai , Rong-
1 2
Shan Li *, Xin-Chun Yang *
1 Department of Nephrology and Hemodialysis Center, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China, 2 Department of Cardiology, Chaoyang
Hospital, Capital Medical University, Beijing, China, 3 Department of Cardiology, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China, 4 Medical College of
Xiamen University, Xiamen, Fujian, China
Abstract
Objective: An insertion/deletion (I/D) variant in the angiotensin-converting enzyme (ACE) gene was associated with ACE
inhibitor (ACEI)–related cough in previous studies. However, the results were inconsistent. Our objective was to assess the
relationship between the ACE I/D polymorphism and ACEI-related cough by meta-analysis and to summarize all studies that
are related to ACE I/D polymorphism and ACEI-cough and make a summary conclusion to provide reference for the
researchers who attempt to conduct such a study.
Methods: Databases including PubMed, EMbase, Cochrane Library, and China National Knowledge Infrastructure, were
searched for genetic association studies. Data were extracted by two independent authors and pooled odds ratio (OR) with
95% confidence interval (CI) was calculated. Metaregression and subgroup analyses were performed to identify the source
of heterogeneity.
Results: Eleven trials, including 906 cases (ACEI-related cough) and 1,175 controls, were reviewed in the present meta-
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