an information-theoretic analysis of genetics, gender and age in cancer patients信息理论分析的遗传学,癌症患者的性别和年龄.pdfVIP
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an information-theoretic analysis of genetics, gender and age in cancer patients信息理论分析的遗传学,癌症患者的性别和年龄
An Information-Theoretic Analysis of Genetics, Gender
and Age in Cancer Patients
1. ´ ´ 1 3 3 ¨ 4,6
Gurinder Singh Atwal , Raul Rabadan , Guillermina Lozano , Louise C. Strong , Marielle W. G. Ruijs ,
5 4 7 7 ¨ 8
Marjanka K. Schmidt , Laura J. van’t Veer , Heli Nevanlinna , Johanna Tommiska , Kristiina Aittomaki ,
9 9 1,2 1.¤
Gaelle Bougeard , Thierry Frebourg , Arnold J. Levine , Gareth L. Bond *
1The Institute for Advanced Study, Princeton, New Jersey, United States of America, 2 The Cancer Institute of New Jersey, New Brunswick, New Jersey, United States of
America, 3 The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, United States of America, 4 Family Cancer Clinic, The Netherlands Cancer Institute,
Amsterdam, The Netherlands, 5 Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands, 6 Department of Clinical Genetics and
Human Genetics, VU University Medical Center, Amsterdam, The Netherlands, 7 Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki,
Finland, 8 Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland, 9 Inserm U614 and Department of Genetics, Rouen University Hospital,
Institute for Biomedical Research, Rouen, France
Abstract
Germline genetics, gender and hormonal-signaling pathways are all well described modifiers of cancer risk and progression.
Although an i
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