an information-theoretic analysis of genetics, gender and age in cancer patients信息理论分析的遗传学,癌症患者的性别和年龄.pdfVIP

an information-theoretic analysis of genetics, gender and age in cancer patients信息理论分析的遗传学,癌症患者的性别和年龄.pdf

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an information-theoretic analysis of genetics, gender and age in cancer patients信息理论分析的遗传学,癌症患者的性别和年龄

An Information-Theoretic Analysis of Genetics, Gender and Age in Cancer Patients 1. ´ ´ 1 3 3 ¨ 4,6 Gurinder Singh Atwal , Raul Rabadan , Guillermina Lozano , Louise C. Strong , Marielle W. G. Ruijs , 5 4 7 7 ¨ 8 Marjanka K. Schmidt , Laura J. van’t Veer , Heli Nevanlinna , Johanna Tommiska , Kristiina Aittomaki , 9 9 1,2 1.¤ Gaelle Bougeard , Thierry Frebourg , Arnold J. Levine , Gareth L. Bond * 1The Institute for Advanced Study, Princeton, New Jersey, United States of America, 2 The Cancer Institute of New Jersey, New Brunswick, New Jersey, United States of America, 3 The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, United States of America, 4 Family Cancer Clinic, The Netherlands Cancer Institute, Amsterdam, The Netherlands, 5 Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands, 6 Department of Clinical Genetics and Human Genetics, VU University Medical Center, Amsterdam, The Netherlands, 7 Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland, 8 Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland, 9 Inserm U614 and Department of Genetics, Rouen University Hospital, Institute for Biomedical Research, Rouen, France Abstract Germline genetics, gender and hormonal-signaling pathways are all well described modifiers of cancer risk and progression. Although an i

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