有哪些信誉好的足球投注网站annexin a1 n-terminal derived peptide ac2-26 stimulates fibroblast migration in high glucose conditions膜联蛋白a1 n端衍生肽ac2-26刺激纤维母细胞在高葡萄糖条件下迁移.pdfVIP
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annexin a1 n-terminal derived peptide ac2-26 stimulates fibroblast migration in high glucose conditions膜联蛋白a1 n端衍生肽ac2-26刺激纤维母细胞在高葡萄糖条件下迁移
Annexin A1 N-Terminal Derived Peptide Ac2-26
Stimulates Fibroblast Migration in High Glucose
Conditions
1 2 ` 1 1 3
Valentina Bizzarro , Bianca Fontanella , Anna Carratu , Raffaella Belvedere , Raffaele Marfella ,
1 1
Luca Parente , Antonello Petrella *
1 Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Salerno, Italy, 2 Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy,
3 Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
Abstract
Deficient wound healing in diabetic patients is very frequent, but the cellular and molecular causes are poorly defined. In
this study, we have evaluated whether Annexin A1 derived peptide Ac2-26 stimulates fibroblast migration in high glucose
conditions. Using normal human skin fibroblasts WS1 in low glucose (LG) or high glucose (HG) we observed the enrichment
of Annexin A1 protein at cell movement structures like lamellipodial extrusions and interestingly, a significant decrease in
levels of the protein in HG conditions. The analysis of the translocation of Annexin A1 to cell membrane showed lower levels
of Annexin A1 in both membrane pool and supernatants of WS1 cells treated with HG. Wound-healing assays using cell line
transfected with Annexin A1 siRNAs indicated a slowing down in migration speed of cells suggesting that Annexin A1 has
a role in the migration of WS1 cells. In order to analyze the role of extracellular Annexin A1 in cell migration, we have
performed wound-healing assays using Ac2-26 showing that peptide was able to increase fibroblast cell migration in HG
conditions. Experiments on the mobilization of intracellular calcium an
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