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an insight into the sialotranscriptome of the cat flea, ctenocephalides felis一个洞察的sialotranscriptome猫跳蚤,ctenocephalides猫属
An Insight into the Sialotranscriptome of the Cat Flea,
Ctenocephalides felis
´ 1 ˜ 1 1 2,3 1
Jose M. C. Ribeiro *, Teresa C. F. Assumpc¸ao , Dongying Ma , Patricia H. Alvarenga , Van M. Pham ,
1 1 4
John F. Andersen , Ivo M. B. Francischetti , Kevin R. Macaluso
1Vector Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Rockville, Maryland, United States of America,
´ ´ ´ ´
2 Laboratorio de Bioquımica de Resposta ao Estresse, Instituto de Bioquımica Medica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, 3 Instituto Nacional de
ˆ
Ciencia e Tecnologia em Entomologia Molecular (INCT-EM), Rio de Janeiro, Brazil, 4 Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State
University, Baton Rouge, Louisiana, United States of America
Abstract
Background: Saliva of hematophagous arthropods contains a diverse mixture of compounds that counteracts host
hemostasis. Immunomodulatory and antiinflammatory components are also found in these organisms’ saliva. Blood feeding
evolved at least ten times within arthropods, providing a scenario of convergent evolution for the solution of the salivary
potion. Perhaps because of immune pressure from hosts, the salivary proteins of related organisms have considerable
divergence, and new protein families are often found within different genera of the sam
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