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an integrin-dependent role of pouch endoderm in hyoid cartilage development一个integrin-dependent舌骨软骨囊内胚层的发展中的作用
Open access, freely available online PLoS BIOLOGY
An Integrin-Dependent Role of Pouch Endoderm
in Hyoid Cartilage Development
*
Justin Gage Crump , Mary E. Swartz, Charles B. Kimmel
Institute of Neuroscience, University of Oregon, Eugene, Oregon, United States of America
Pharyngeal endoderm is essential for and can reprogram development of the head skeleton. Here we investigate the
roles of specific endodermal structures in regulating craniofacial development. We have isolated an integrina5 mutant
in zebrafish that has region-specific losses of facial cartilages derived from hyoid neural crest cells. In addition, the
cranial muscles that normally attach to the affected cartilage region and their associated nerve are secondarily reduced
in integrina5 animals. Earlier in development, integrina5 mutants also have specific defects in the formation of the
first pouch, an outpocketing of the pharyngeal endoderm. By fate mapping, we show that the cartilage regions that are
lost in integrina5 mutants develop from neural crest cells directly adjacent to the first pouch in wild-type animals.
Furthermore, we demonstrate that Integrina5 functions in the endoderm to control pouch formation and cartilage
development. Time-lapse recordings suggest that the first pouch promotes region-specific cartilage development by
regulating the local compaction and survival of skeletogenic neural crest cells. Thus, our results reveal a hierarchy of
tissue interactions, at the top of which is the first endodermal pouch, which locally coordinates the development of
multiple tissues in a specific region of the vertebrate face. Lastly, we discuss the implications of a mosaic assembly of
the facial skeleton for the evolution of ray-finned fish.
Citation: Crump JG, Swartz ME, Kimmel CB (2004) An integrin-dependent role of pouch e
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