有哪些信誉好的足球投注网站an interaction between kshv orf57 and uif provides mrna-adaptor redundancy in herpesvirus intronless mrna export之间的一个互动kshv orf57和uif提供mrna-adaptor冗余在疱疹病毒intronless mrna出口.pdfVIP
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an interaction between kshv orf57 and uif provides mrna-adaptor redundancy in herpesvirus intronless mrna export之间的一个互动kshv orf57和uif提供mrna-adaptor冗余在疱疹病毒intronless mrna出口
An Interaction between KSHV ORF57 and UIF Provides
mRNA-Adaptor Redundancy in Herpesvirus Intronless
mRNA Export
1,2 1¤ 1,2 1,2 3
Brian R. Jackson , James R. Boyne , Marko Noerenberg , Adam Taylor , Guillaume M. Hautbergue ,
3 4 4 3 1,2
Matthew J. Walsh , Rachel Wheat , David J. Blackbourn , Stuart A. Wilson , Adrian Whitehouse *
1 Institute of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom, 2 Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds,
United Kingdom, 3 Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom, 4 School of Cancer Sciences, College of
Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
Abstract
The hTREX complex mediates cellular bulk mRNA nuclear export by recruiting the nuclear export factor, TAP, via a direct
interaction with the export adaptor, Aly. Intriguingly however, depletion of Aly only leads to a modest reduction in cellular
mRNA nuclear export, suggesting the existence of additional mRNA nuclear export adaptor proteins. In order to efficiently
export Kaposi’s sarcoma-associated herpesvirus (KSHV) intronless mRNAs from the nucleus, the KSHV ORF57 protein recruits
hTREX onto viral intronless mRNAs allowing access to the TAP-mediated export pathway. Similarly however, depletion of Aly
only leads to a modest reduction in the nuclear export of KSHV intronless mRNAs. Herein, we identify a novel interaction
between ORF57 and the cellular protein, UIF.
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