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altered cerebellar-cerebral functional connectivity in geriatric depression改变cerebellar-cerebral功能连通性在老年抑郁症
Altered Cerebellar-Cerebral Functional Connectivity in
Geriatric Depression
1 2 3 3 2,3
Emmanuel Alalade , Kevin Denny , Guy Potter , David Steffens , Lihong Wang *
1 Morehouse School of Medicine, Atlanta, Georgia, United States of America, 2 Brain Imaging and Analysis Center, Duke University Medical Center, Durham, North
Carolina, United States of America, 3 Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, United States of America
Abstract
Although volumetric and activation changes in the cerebellum have frequently been reported in studies on major
depression, its role in the neural mechanism of depression remains unclear. To understand how the cerebellum may relate
to affective and cognitive dysfunction in depression, we investigated the resting-state functional connectivity between
cerebellar regions and the cerebral cortex in samples of patients with geriatric depression (n = 11) and healthy controls
(n = 18). Seed-based connectivity analyses were conducted using seeds from cerebellum regions previously identified as
being involved in the executive, default-mode, affective-limbic, and motor networks. The results revealed that, compared
with controls, individuals with depression show reduced functional connectivity between several cerebellum seed regions,
specifically those in the executive and affective-limbic networks with the ventromedial prefrontal cortex (vmPFC) and
increased functional connectivity between the motor-related cerebellum seed regions with the putamen and motor cortex.
We further investigated whether the altered functional connectivity i
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