有哪些信誉好的足球投注网站an integrative view of mechanisms underlying generalized spike-and-wave epileptic seizures and its implication on optimal therapeutic treatments广义的综合视图机制spike-and-wave癫痫发作及其含义最佳治疗治疗.pdfVIP
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an integrative view of mechanisms underlying generalized spike-and-wave epileptic seizures and its implication on optimal therapeutic treatments广义的综合视图机制spike-and-wave癫痫发作及其含义最佳治疗治疗
An Integrative View of Mechanisms Underlying
Generalized Spike-and-Wave Epileptic Seizures and Its
Implication on Optimal Therapeutic Treatments
1 2
Boyuan Yan *, Peng Li
1 Department of Electrical and Computer Engineering, Texas AM University, College Station, Texas, United States of America, 2 Department of Electrical and Computer
Engineering, Texas AM University, College Station, Texas, United States of America
Abstract
Many types of epileptic seizures are characterized by generalized spike-and-wave discharges. In the past, notable effort has
been devoted to understanding seizure dynamics and various hypotheses have been proposed to explain the underlying
mechanisms. In this paper, by taking an integrative view of the underlying mechanisms, we demonstrate that epileptic
seizures can be generated by many different combinations of synaptic strengths and intrinsic membrane properties. This
integrative view has important medical implications: the specific state of a patient characterized by a set of biophysical
characteristics ultimately determines the optimal therapeutic treatment. Through the same view, we further demonstrate
the potentiation effect of rational polypharmacy in the treatment of epilepsy and provide a new angle to resolve the debate
on polypharmacy. Our results underscore the need for personalized medicine and demonstrate that computer modeling
and simulation may play an important role in assisting the clinicians in selecting the optimal treatment on an individual
basis.
Citation: Yan B, Li P (2011) An Integrative View of Mechanisms Underlying Generalized Spike-and-Wave Epileptic Seizures and Its Implication on Optimal
Therapeutic Treatments. PLoS ONE 6(7): e22440. doi:10.1371/journal.pone.0022440
Editor: Vladimir Brezina, Mount Sinai School of Medicine, United States of America
Rec
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