alterations in the aedes aegypti transcriptome during infection with west nile, dengue and yellow fever viruses改变在埃及伊蚊转录组感染西尼罗河病毒、登革热和黄热病病毒.pdfVIP

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alterations in the aedes aegypti transcriptome during infection with west nile, dengue and yellow fever viruses改变在埃及伊蚊转录组感染西尼罗河病毒、登革热和黄热病病毒.pdf

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alterations in the aedes aegypti transcriptome during infection with west nile, dengue and yellow fever viruses改变在埃及伊蚊转录组感染西尼罗河病毒、登革热和黄热病病毒

Alterations in the Aedes aegypti Transcriptome during Infection with West Nile, Dengue and Yellow Fever Viruses 1 1¤a 2 1,3 1 Tonya M. Colpitts , Jonathan Cox , Dana L. Vanlandingham , Fabiana M. Feitosa , Gong Cheng , 1 1 1¤b 2 1,3 Sebastian Kurscheid , Penghua Wang , Manoj N. Krishnan , Stephen Higgs , Erol Fikrig * 1 Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, 2 Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America, 3 Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America Abstract West Nile (WNV), dengue (DENV) and yellow fever (YFV) viruses are (re)emerging, mosquito-borne flaviviruses that cause human disease and mortality worldwide. Alterations in mosquito gene expression common and unique to individual flaviviral infections are poorly understood. Here, we present a microarray analysis of the Aedes aegypti transcriptome over time during infection with DENV, WNV or YFV. We identified 203 mosquito genes that were $5-fold differentially up- regulated (DUR) and 202 genes that were $10-fold differentially down-regulated (DDR) during infection with one of the three flaviviruses. Comparative analysis revealed that the expression profile of 20 DUR genes and 15 DDR genes was quite similar between the three flaviviruses on D1 of infection, indicating a potentially conserved transcriptomic signa