an intense and short-lasting burst of neutrophil activation differentiates early acute myocardial infarction from systemic inflammatory syndromes激烈,而且持续的嗜中性粒细胞激活区分从系统性炎症综合征早期急性心肌梗死.pdfVIP
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an intense and short-lasting burst of neutrophil activation differentiates early acute myocardial infarction from systemic inflammatory syndromes激烈,而且持续的嗜中性粒细胞激活区分从系统性炎症综合征早期急性心肌梗死
An Intense and Short-Lasting Burst of Neutrophil
Activation Differentiates Early Acute Myocardial
Infarction from Systemic Inflammatory Syndromes
1 1 2 1 3
Norma Maugeri *, Patrizia Rovere-Querini , Virgilio Evangelista , Cosmo Godino , Monica Demetrio ,
1 1 1 1 3 3
Mattia Baldini , Filippo Figini , Giovanni Coppi , Massimo Slavich , Marina Camera , Antonio Bartorelli ,
3 1 1 1 1
Giancarlo Marenzi , Lara Campana , Elena Baldissera , Maria Grazia Sabbadini , Domenico Cianflone ,
3 1 1 1,4
Elena Tremoli , Armando D’Angelo , Angelo A. Manfredi , Attilio Maseri
`
1 Universita Vita-Salute San Raffaele and San Raffaele Scientific Institute, Milano, Italy, 2 Istituto Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy, 3 Centro
Cardiologico Monzino, Milano Italy, 4 Heart Care Foundation, Florence, Italy
Abstract
Background: Neutrophils are involved in thrombus formation. We investigated whether specific features of neutrophil
activation characterize patients with acute coronary syndromes (ACS) compared to stable angina and to systemic
inflammatory diseases.
Methods and Findings: The myeloperoxidase (MPO) content of circulating neutrophils was determined by flow cytometry
in 330 subjects: 69 consecutive patients with acute coronary syndromes (ACS), 69 with chronic stable angina (CSA), 50 wi
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