有哪些信誉好的足球投注网站an integrated epigenetic and genetic analysis of dna methyltransferase genes (dnmts) in tumor resistant and susceptible chicken lines一个集成的表观遗传和基因分析dna甲基转移酶基因(dnmts)肿瘤耐药和易感鸡行.pdfVIP
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an integrated epigenetic and genetic analysis of dna methyltransferase genes (dnmts) in tumor resistant and susceptible chicken lines一个集成的表观遗传和基因分析dna甲基转移酶基因(dnmts)肿瘤耐药和易感鸡行
An Integrated Epigenetic and Genetic Analysis of DNA
Methyltransferase Genes (DNMTs) in Tumor Resistant
and Susceptible Chicken Lines
1¤ 2 1 1 3 1
Ying Yu , Huanmin Zhang , Fei Tian , Wensheng Zhang , Hongbin Fang , Jiuzhou Song *
1 Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland, United State of America, 2 Agriculture Research Service (ARS), United States
Department of Agriculture (USDA), Avian Disease and Oncology Laboratory, East Lansing, Michigan, United State of America, 3 Division of Biostatistics of The University of
Maryland Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, United State of America
Abstract
Both epigenetic alterations and genetic variations play essential roles in tumorigenesis. The epigenetic modification of DNA
methylation is catalyzed and maintained by the DNA methyltransferases (DNMT3a, DNMT3b and DNMT1). DNA mutations
and DNA methylation profiles of DNMTs themselves and their relationships with chicken neoplastic disease resistance and
susceptibility are not yet defined. In the present study, we analyzed the complexity of the DNA methylation variations and
DNA mutations in the first exon of three DNMTs genes over generations, tissues, and ages among chickens of two highly
inbred White Leghorn lines, Marek’s disease-resistant line 6 and -susceptible line 7 , and six recombinant congenic strains
3 2
(RCSs). Among them, tissue-specific methylation patterns of DNMT3a were disclosed in spleen, liver, and hypothalamus in
lines 6 and 7 . The methylation level of DNMT3b on four CpG sites was not significantly different among four tissues of the
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