alpha-toxin induces programmed cell death of human t cells, b cells, and monocytes during usa300 infectionalpha-toxin诱发细胞程序性死亡的人类t细胞,b细胞,单核细胞在usa300感染.pdfVIP

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alpha-toxin induces programmed cell death of human t cells, b cells, and monocytes during usa300 infectionalpha-toxin诱发细胞程序性死亡的人类t细胞,b细胞,单核细胞在usa300感染.pdf

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alpha-toxin induces programmed cell death of human t cells, b cells, and monocytes during usa300 infectionalpha-toxin诱发细胞程序性死亡的人类t细胞,b细胞,单核细胞在usa300感染

Alpha-Toxin Induces Programmed Cell Death of Human T cells, B cells, and Monocytes during USA300 Infection 1 1 2 1 1 Tyler K. Nygaard , Kyler B. Pallister , Ashley L. DuMont , Mark DeWald , Robert L. Watkins , 1 3 1 3 2 Erik Q. Pallister , Cheryl Malone , Shannon Griffith , Alexander R. Horswill , Victor J. Torres , Jovanka M. Voyich1* 1 Department of Immunology and Infectious Diseases, Montana State University – Bozeman, Montana, United States of America, 2 Department of Microbiology, New York University School of Medicine, New York, New York, United States of America, 3 Department of Microbiology University of Iowa, Iowa City, Iowa, United States of America Abstract This investigation examines the influence of alpha-toxin (Hla) during USA300 infection of human leukocytes. Survival of an USA300 isogenic deletion mutant of hla (USA300Dhla) in human blood was comparable to the parental wild-type strain and polymorphonuclear leukocyte (PMN) plasma membrane permeability caused by USA300 did not require Hla. Flow cytometry analysis of peripheral blood mononuclear cells (PBMCs) following infection by USA300, USA300Dhla, and USA300Dhla transformed with a plasmid over-expressing Hla (USA300Dhla Comp) demonstrated this toxin plays a significant role inducing plasma membrane permeability of CD14+ + + , CD3 , and CD19 PBMCs. Rapid plasma membrane permeability independent of Hla was obse