alterations in glutathione redox metabolism, oxidative stress, and mitochondrial function in the left ventricle of elderly zucker diabetic fatty rat heart改变谷胱甘肽氧化还原代谢、氧化应激和线粒体功能的左心室老年糖尿病脂肪zucker鼠的心.pdfVIP

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alterations in glutathione redox metabolism, oxidative stress, and mitochondrial function in the left ventricle of elderly zucker diabetic fatty rat heart改变谷胱甘肽氧化还原代谢、氧化应激和线粒体功能的左心室老年糖尿病脂肪zucker鼠的心.pdf

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alterations in glutathione redox metabolism, oxidative stress, and mitochondrial function in the left ventricle of elderly zucker diabetic fatty rat heart改变谷胱甘肽氧化还原代谢、氧化应激和线粒体功能的左心室老年糖尿病脂肪zucker鼠的心

Int. J. Mol. Sci. 2012, 13, 16241-16254; doi:10.3390/ijms131216241 OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Alterations in Glutathione Redox Metabolism, Oxidative Stress, and Mitochondrial Function in the Left Ventricle of Elderly Zucker Diabetic Fatty Rat Heart Haider Raza 1,*, Annie John 1 and Frank C. Howarth 2 1 Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, P.O. Box 17666, UAE; E-Mail: anniej@uaeu.ac.ae 2 Department of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, P.O. Box 17666, UAE; E-Mail: chris.howarth@uaeu.ac.ae * Author to whom correspondence should be addressed; E-Mail: h.raza@uaeu.ac.ae; Tel.: +971-3-7137506; Fax: +971-3-7672033. Received: 20 September 2012; in revised form: 31 October 2012 / Accepted: 19 November 2012 / Published: 30 November 2012 Abstract: The Zucker diabetic fatty (ZDF) rat is a genetic model in which the homozygous (FA/FA) male animals develop obesity and type 2 diabetes. Morbidity and mortality from cardiovascular complications, due to increased oxidative stress and inflammatory signals, are the hallmarks of type 2 diabetes. The precise molecular mechanism of contractile dysfunction and disease progression remains to be clarified. Therefore, we have investigated molecular and metabolic targets i