an integrated gene regulatory network controls stem cell proliferation in teeth一个集成的基因调控网络控制干细胞增殖的牙齿.pdfVIP

PLoS BIOLOGY An Integrated Gene Regulatory Network Controls Stem Cell Proliferation in Teeth 1,2[ 1[ 1 3 3,4 Xiu-Ping Wang , Marika Suomalainen , Szabolcs Felszeghy , Laura C. Zelarayan , Maria T. Alonso , Maksim V. Plikus5 2 5 3,4 1* , Richard L. Maas , Cheng-Ming Chuong , Thomas Schimmang , Irma Thesleff 1 Developmental Biology Programme, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland, 2 Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, 3 Center for Molecular Neurobiology Hamburg, University of Hamburg, Hamburg, Germany, 4 Institute for Biology and Molecular Genetics, Superior Research Council and University of Valladolid, Valladolid, Spain, 5 Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America Epithelial stem cells reside in specific niches that regulate their self-renewal and differentiation, and are responsible for the continuous regeneration of tissues such as hair, skin, and gut. Although the regenerative potential of mammalian teeth is limited, mouse incisors grow continuously throughout life and contain stem cells at their proximal ends in the cervical loops. In the labial cervical loop, the epithelial stem cells proliferate and migrate along the labial surface, differentiating into enamel-forming ameloblasts. In contrast, the lingual cervical loop contains fewe