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alterations of micrornas in solid cancers and their prognostic value小分子核糖核酸的改变固体癌症及其预后价值.pdf

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alterations of micrornas in solid cancers and their prognostic value小分子核糖核酸的改变固体癌症及其预后价值

Cancers 2010, 2, 1328-1353; doi:10.3390/cancers2021328 OPEN ACCESS cancers ISSN 2072-6694 /journal/cancers Review Alterations of MicroRNAs in Solid Cancers and Their Prognostic Value Panagiota Chira 1,2, Katerina Vareli 1,3, Ioannis Sainis 1, Christos Papandreou 4 and Evangelos Briasoulis 1,5,* 1 Human Cancer Biobank Center, University of Ioannina, University Campus, Ioannina 45110, Greece; E-Mails: panagiotachira@ (P.C.); kvareli@cc.uoi.gr (K.V.); isainis@cc.uoi.gr (I.S.) 2 Biomedical Research Institute, Foundation for Research Technology, University Campus, Ioannina 45110, Greece 3 Department of Biological Applications and Technologies, University of Ioannina, University Campus, Ioannina 45110, Greece 4 School of Medicine, University of Thessaly, 22 Papakiriazi, Larissa 41222, Greece; E-Mail: cpapandreou@med.uth.gr (C.P.) 5 School of Medicine, University of Ioannina, University Campus, Ioannina 45110, Greece * Author to whom correspondence should be addressed; E-Mail: ebriasou@otenet.gr or ebriasou@; Tel.: +30-265-100-7713; Fax: +30-265-100-8087. Received: 23 April 2010; in revised form: 2 June 2010 / Accepted: 10 June 2010 / Published: 14 June 2010 Abstract: MicroRNAs (miRNAs) are evolutionarily conserved, naturally abundant, small, regulatory non-coding RNAs that inhibit gene expression at the post-transcriptional level in a sequence-specific manner. Each miRNA represses the protein expression of several coding genes in a manner proportional to the sequence complementarity with the target