alteration of gene expression profile in niemann-pick type c mice correlates with tissue damage and oxidative stress改变基因表达谱的尼曼c小鼠与组织损伤和氧化应激.pdfVIP
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alteration of gene expression profile in niemann-pick type c mice correlates with tissue damage and oxidative stress改变基因表达谱的尼曼c小鼠与组织损伤和氧化应激
Alteration of Gene Expression Profile in Niemann-Pick
Type C Mice Correlates with Tissue Damage and
Oxidative Stress
´ 1 ´ 2,5 ´ 1 3 2
Mary C. Vazquez , Talıa del Pozo , Fermın A. Robledo , Gonzalo Carrasco , Leonardo Pavez , Felipe
2 ´ 2,4,5 1,5
Olivares , Mauricio Gonzalez , Silvana Zanlungo *
´ ´ ´ ´ ´
1 Departamento de Gastroenterologıa, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile, 2 Laboratorio de Bioinformatica y Expresion Genica,
´ ´ ´
INTA, Universidad de Chile, Santiago, Chile, 3 Fundacion Hospital Parroquial de San Bernardo, Santiago, Chile, 4 Laboratorio de Bioinformatica y Matematicas del Genoma,
´ ´ ´
Centro de Modelamiento Matematico (CMM), Facultad de Ciencias Fısicas y Matematicas, Universidad de Chile, Santiago, Chile, 5 FONDAP-Center of Genome Regulation
(CGR), Santiago, Chile
Abstract
Background: Niemann-Pick type C disease (NPC) is a neurovisceral lipid storage disorder mainly characterized by
unesterified cholesterol accumulation in lysosomal/late endosomal compartments, although there is also an important
storage for several other kind of lipids. The main tissues affected by the dis
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