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an integrative genomic and epigenomic approach for the study of transcriptional regulation一个综合基因组和转录调控外遗传性研究方法
An Integrative Genomic and Epigenomic Approach for
the Study of Transcriptional Regulation
1. 2. 3 4 1 5
Maria E. Figueroa , Mark Reimers , Reid F. Thompson , Kenny Ye , Yushan Li , Rebecca R. Selzer ,
5 6 6 5 3,7
Jakob Fridriksson , Elisabeth Paietta , Peter Wiernik , Roland D. Green , John M. Greally *, Ari
Melnick1*
1 Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America, 2 Department of Biostatistics,
Virginia Commonwealth University, Richmond, Virginia, United States of America, 3 Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New
York, United States of America, 4 Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, United States of America,
5 Roche NimbleGen, Inc. Madison, Wisconsin, United States of America, 6 Our Lady of Mercy Comprehensive Cancer Center, Bronx, New York, United States of America,
7 Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America
Abstract
The molecular heterogeneity of acute leukemias and other tumors constitutes a major obstacle towards understanding
disease pathogenesis and developing new targeted-therapies. Aberrant gene regulation is a hallmark of cancer and plays a
central role in determining tumor phenotype. We predicted that integration of different genome-wide epigenetic regulatory
marks along with gene expression levels would provide greater power in capturing biological differences between leukemia
subt
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