an insertion sequence-dependent plasmid rearrangement in aeromonas salmonicida causes the loss of the type three secretion system气单胞菌属的插入顺序相依质粒重组salmonicida原因三型分泌系统的损失.pdfVIP

An Insertion Sequence-Dependent Plasmid Rearrangement in Aeromonas salmonicida Causes the Loss of the Type Three Secretion System 1,2 ´ 1,2 1,2¤ 3,4 Katherine H. Tanaka , Stephanie Dallaire-Dufresne , Rana K. Daher , Michel Frenette , Steve J. Charette1,2,3* ´ ` ` ´ 1 Institut de biologie integrative et des systemes, Pavillon Charles-Eugene-Marchand, Universite Laval, Quebec City, Quebec, Canada, 2 Centre de recherche de l’Institut ´ ´ ´ universitaire de cardiologie et de pneumologie de Quebec, Quebec City, Quebec, Canada, 3 Departement de biochimie, de microbiologie et de bio-informatique, Faculte ´ ´ ´ ´ ´ ´ des sciences et de genie, Universite Laval, Quebec City, Quebec, Canada, 4 Groupe de Recherche en Ecologie Buccale, Faculte de medecine dentaire, Universite Laval, Quebec City, Quebec, Canada Abstract Aeromonas salmonicida, a bacterial fish pathogen, possesses a functional Type Three Secretion System (TTSS), which is essential for its virulence. The genes for this system are mainly located in a single region of the large pAsa5 plasmid. Bacteria lose the TTSS region from this plasmid through rearrangements when grown in stressful growth conditions